Execution of ASK1-induced Apoptosis by the Mitochondria-dependent Caspase Activation*

From the ‡Laboratory of Cell Signaling, Department of Hard Tissue Engineering, Division of Bio-Matrix, the §Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, and the | Homeostasis Medicine, Department of Regulation of Internal Environment and Reproduction, Division of Systemic Organ Regulation, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan, the #Institute for Virus Research, Kyoto University, Kawahara-cho, Shogoin, Sakyoku, Kyoto 606-8507, Japan, the †Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, and the || Central Research Laboratories, Kissei Pharmaceutical Co., Ltd. , 4365-1 Kashiwabara, Hotaka, Minamiazumi, Nagano 399-8304, Japan. ¶To whom correspondence should be addressed: Cell Signaling, Department of Hard Tissue Engineering, Division of Bio-Matrix, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan Phone: +81-3-5803-5471 Fax : +81-3-5803-0192 E-mail: [email protected]